Getting used to using your keyboard exclusively and leaving your mouse behind will make you much more efficient at performing any task on any Windows system. I use the following keyboard shortcuts every day:

Windows key + R = Run menu

This is usually followed by:
cmd = Command Prompt
iexplore + "web address" = Internet Explorer
compmgmt.msc = Computer Management
dhcpmgmt.msc = DHCP Management
dnsmgmt.msc = DNS Management
services.msc = Services
eventvwr = Event Viewer
dsa.msc = Active Directory Users and Computers
dssite.msc = Active Directory Sites and Services
Windows key + E = Explorer

ALT + Tab = Switch between windows

ALT, Space, X = Maximize window

CTRL + Shift + Esc = Task Manager

Windows key + Break = System properties

Windows key + F = Search

Windows key + D = Hide/Display all windows

CTRL + C = copy

CTRL + X = cut

CTRL + V = paste

Also don't forget about the "Right-click" key next to the right Windows key on your keyboard. Using the arrows and that key can get just about anything done once you've opened up any program.

Keyboard Shortcuts

[Alt] and [Esc] Switch between running applications

[Alt] and letter Select menu item by underlined letter

[Ctrl] and [Esc] Open Program Menu

[Ctrl] and [F4] Close active document or group windows (does not work with some applications)

[Alt] and [F4] Quit active application or close current window

[Alt] and [-] Open Control menu for active document

Ctrl] Lft., Rt. arrow Move cursor forward or back one word

Ctrl] Up, Down arrow Move cursor forward or back one paragraph

[F1] Open Help for active application

Windows+M Minimize all open windows

Shift+Windows+M Undo minimize all open windows

Windows+F1 Open Windows Help

Windows+Tab Cycle through the Taskbar buttons

Windows+Break Open the System Properties dialog box